Wanqing Liu

Adjunct Professor of Medicinal Chemistry and Molecular Pharmacology
Specialization: Disease Genomics, Pharmacogenomics and Personalized Medicine, Systems Biology


B.S. - Shandong Normal University, China, 1996
Ph.D - Shanghai Institute of Physiology, Chinese Academy of Sciences, 2001
Research Associate - The University of Chicago, 2002-2005
Research Associate (Assistant Professor) - The University of Chicago, 2005-2011

Lab Members

Omaima Salaheldin Somida Awad Ali (Visiting Scholar)
Shaminie Athinarayanan (PULSE Graduate Student)


**Our lab is currently recruiting graduate students and postdoctoral fellows interested in molecular genetics, genomics and systems biology, as well as computational data analysis and bioinformatics. Please contact Dr. Liu for further information.


The long-term interest of my lab is focused on human disease genomics and personalized medicine towards discovering genetic markers integral to human diseases and therapeutic treatments, as well as translating these markers into clinical practice. My current research involves the use of integrated “omics” and a systems approach to identifying susceptibility genetic variants and molecular targets for disease pathogenesis and therapeutics. Ongoing projects in the lab include:

1) The genetics and genomics of human central metabolism and liver disease. We use a systems biology approach to identifying genetic factors affecting impaired lipid metabolism and deposition in the liver, a central component of multiple liver diseases and metabolic complications.

2) Pharmacogenetics and genomics. We are interested in identifying genetic variants and molecular markers leading to inter-individual differences in efficacy and side effects of therapeutic agents. We use various approaches to understand the underlying mechanism of how genetic variants alter drug metabolism, and the transportation and disposition in humans.

3) Genetics of lung cancer and lung disease. We employ a genome-wide approach, as well as mechanistic strategies to understand how heritable genetic variations confer risks to the genesis of somatic alterations in lung cancer.

The technologies used in our lab include: RNA/DNA extraction, PCR, quantitative PCR, genotyping, sequencing, microarray, tissue culture and treatment, other techniques for studying transcriptional regulation of gene expression (reporter gene, cloning, gel shift, etc.), as well as genome-wide and high-throughput approaches including various genomic, transcriptomic, miRNomic and metabolomic techniques. We also use computational analysis and bioinformatic annotation of genetic, genomic and systems biology data.

Representative Publications

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