Rong Huang

Project 1: Targeting Methyltransferases to discover new drugs

Project 2: Targeting Protein α-N-terminal Acetylation

Our lab applies a multidisciplinary approach to: 

• Elucidate the mechanisms and functions of epigenetic modifications including methylation and  acetylation 
• Rational design and synthesize selective and potent inhibitors for protein methyltransferases and alpha N-terminal acetyltransferases
• Develop novel therapeutic agents for cancer and other diseased through targeting epigenetic pathways 

Please see: http://www.rhuanglab.com for detailed information.

MCMP205

NIH R01GM117275

NIH U01CA214649

Purdue University College of Pharmacy Startup Funds

Chen D, Dong G, Noinaj N, Huang R. (2019) Discovery of bisubstrate inhibitors for protein N-terminal methyltransferase 1. Journal of Medicinal Chemistry. March 18, 2019. pubs.acs.org/doi/10.1021/acs.jmedchem.9b00206

Huang R. (2018) Chemical biology of protein N-terminal methyltransferases. ChemBioChem. Young Researcher Issue: ChemBioTalents.  November 26, 2018. PMID: 30479015​. http://onlinelibrary.wiley.com/doi/10.1002/cbic.201800615.

Cheng D, Dong G., Li L, Zhu L., Tempel W, Liu Y, Huang R*, and Jin M*. (2018) An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Communications Biology. 1, 183. PMID: 30417120. PMCID: PMC6214909 (* co-corresponding  authors) www.nature.com/articles/s42003-018-0196-2

Kronfol MM, Dozmorov MG, Huang R, Slattum PW and McClay JL (2017) The role of epigenomics in personalized medicine. Expert Review of Precision Medicine and Drug Development. 2(1), 33-45. 

Khalil EM, Mackie BD, Mao Y, and Huang R. (2016) Methyltransferases: Key Regulators in Cardiovascular Development and Disease. Annals of Vascular Medicine and Research. 3(2): 1032. Invited Review Link

Zhang G, Huang R. (2016) Facile Synthesis of SAM-Peptide Conjugates through Alkyl Linkers Targeting Protein N-terminal Methyltransferase 1. RSC Advance, 6, 6768-6771. Link

Cheng D, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R*, and Jin M*. (2015) Structural basis for the substrate recognition by the human N-terminal methyltransferase 1. Gene & Development, 29 (22), 2343-2348. PMID: 26543161. PMCID:PMC4691889 (* co-corresponding  authors) Link

Richardson SL, Mao Y, Zhang G, Hanjra P, Peterson DL, Huang R. (2015) Mechanistic studies of protein N-terminal RCC1 methyltransferase 1. Journal of Biological Chemistry, 290 (18), 11601-11610. PMID: 25771539. PMCID:PMC4416863 Link

Richardson SL, Hanjra P, Zhang G, Mackie BD, Peterson DL, Huang R. (2015) A Direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases. Analytical Biochemistry: Methods in the Biological Sciences, 478, 59-64. PMID: 25778392. PMCID: PMC4855292. Link

Zhang G, Richardson SL, Mao Y, Huang R. (2015) Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors. Organic & Biomolecular Chemistry. 13, 4149-4154. PMID: 25712161. PMCID: PMC4857722. Link
This work was highlighted in its front cover image.