M.S. - 1999 Tongji Medical University (Pharmaceutical Science)
Ph.D. -2006 Purdue University (Medicinal Chemistry)
Postdoc. -2007-2011 Johns Hopkins University (Chemical Biology)
Project 1: Targeting Methyltransferases to discover new drugs
Project 2: Targeting Protein α-N-terminal Acetylation
Our lab applies a multidisciplinary approach to:
- Elucidate the mechanisms and functions of epigenetic modifications including methylation and acetylation
- Rational design and synthesize selective and potent inhibitors for protein methyltransferases and alpha N-terminal acetyltransferases
- Develop novel therapeutic agents for cancer and other diseased through targeting epigenetic pathways
Please see: http://www.rhuanglab.com for detailed information.
Purdue University College of Pharmacy Startup Funds
Chen D, Dong G, Noinaj N, Huang R. (2019) Discovery of bisubstrate inhibitors for protein N-terminal methyltransferase 1. Journal of Medicinal Chemistry. March 18, 2019. pubs.acs.org/doi/10.1021/acs.jmedchem.9b00206
Huang R. (2018) Chemical biology of protein N-terminal methyltransferases. ChemBioChem. Young Researcher Issue: ChemBioTalents. November 26, 2018. PMID: 30479015âï¿½ï¿½. http://onlinelibrary.wiley.com/doi/10.1002/cbic.201800615.
Cheng D, Dong G., Li L, Zhu L., Tempel W, Liu Y, Huang R*, and Jin M*. (2018) An asparagine/glycine switch governs product specificity of human N-terminal methyltransferase NTMT2. Communications Biology. 1, 183. PMID: 30417120. PMCID: PMC6214909 (* co-corresponding authors) www.nature.com/articles/s42003-018-0196-2
Kronfol MM, Dozmorov MG, Huang R, Slattum PW and McClay JL (2017) The role of epigenomics in personalized medicine. Expert Review of Precision Medicine and Drug Development. 2(1), 33-45.
Khalil EM, Mackie BD, Mao Y, and Huang R. (2016) Methyltransferases: Key Regulators in Cardiovascular Development and Disease. Annals of Vascular Medicine and Research. 3(2): 1032. Invited Review Link
Zhang G, Huang R. (2016) Facile Synthesis of SAM-Peptide Conjugates through Alkyl Linkers Targeting Protein N-terminal Methyltransferase 1. RSC Advance, 6, 6768-6771. Link
Cheng D, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R*, and Jin M*. (2015) Structural basis for the substrate recognition by the human N-terminal methyltransferase 1. Gene & Development, 29 (22), 2343-2348. PMID: 26543161. PMCID:PMC4691889 (* co-corresponding authors) Link
Richardson SL, Mao Y, Zhang G, Hanjra P, Peterson DL, Huang R. (2015) Mechanistic studies of protein N-terminal RCC1 methyltransferase 1. Journal of Biological Chemistry, 290 (18), 11601-11610. PMID: 25771539. PMCID:PMC4416863 Link
Richardson SL, Hanjra P, Zhang G, Mackie BD, Peterson DL, Huang R. (2015) A Direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases. Analytical Biochemistry: Methods in the Biological Sciences, 478, 59-64. PMID: 25778392. PMCID: PMC4855292. Link
Zhang G, Richardson SL, Mao Y, Huang R. (2015) Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors. Organic & Biomolecular Chemistry. 13, 4149-4154. PMID: 25712161. PMCID: PMC4857722. Link
This work was highlighted in its front cover image.