M.S. - 1999 Tongji Medical University (Pharmaceutical Science)
Ph.D. -2006 Purdue University (Medicinal Chemistry)
Postdoc. -2007-2011 Johns Hopkins University (Chemical Biology)
Please see: http://www.rhuanglab.com for detailed information
Our lab applies a multidisciplinary approach encompassing the fields of biochemistry, organic and peptide synthesis, chemoproteomics, and cell biology.
- Understanding the molecular mechanisms of protein post-translational modifications including methylation, acetylation, and phosphorylation
- Design and synthesis of selective and potent inhibitors including new small molecules, peptidomimetics, and peptide conjugates to manipulate and probe the epigenetic pathways
- Development of novel and targeted epigenetic therapies for cancer and other diseases
Kronfol MM, Dozmorov MG, Huang R, Slattum PW and McClay JL (2017) The role of epigenomics in personalized medicine. Expert Review of Precision Medicine and Drug Development. 2(1), 33-45.
Khalil EM, Mackie BD, Mao Y, and Huang R. (2016) Methyltransferases: Key Regulators in Cardiovascular Development and Disease. Annals of Vascular Medicine and Research. 3(2): 1032. Invited Review Link
Zhang G, Huang R. (2016) Facile Synthesis of SAM-Peptide Conjugates through Alkyl Linkers Targeting Protein N-terminal Methyltransferase 1. RSC Advance, 6, 6768-6771. Link
Cheng D, Mao Y, Tempel W, Qin S, Li L, Loppnau P, Huang R*, and Jin M*. (2015) Structural basis for the substrate recognition by the human N-terminal methyltransferase 1. Gene & Development, 29 (22), 2343-2348. PMID: 26543161. PMCID:PMC4691889 (* co-corresponding authors) Link
Richardson SL, Mao Y, Zhang G, Hanjra P, Peterson DL, Huang R. (2015) Mechanistic studies of protein N-terminal RCC1 methyltransferase 1. Journal of Biological Chemistry, 290 (18), 11601-11610. PMID: 25771539. PMCID:PMC4416863 Link
Richardson SL, Hanjra P, Zhang G, Mackie BD, Peterson DL, Huang R. (2015) A Direct, ratiometric, and quantitative MALDI-MS assay for protein methyltransferases and acetyltransferases. Analytical Biochemistry: Methods in the Biological Sciences, 478, 59-64. PMID: 25778392. PMCID: PMC4855292. Link
Zhang G, Richardson SL, Mao Y, Huang R. (2015) Design, synthesis, and kinetic analysis of potent protein N-terminal methyltransferase 1 inhibitors. Organic & Biomolecular Chemistry. 13, 4149-4154. PMID: 25712161. PMCID: PMC4857722. Link
This work was highlighted in its front cover image.