Photo of Donald E. Bergstrom
Donald E. Bergstrom
Professor Emeritus of Medicinal Chemistry
Specialization: Complex Molecule Design and Synthesis
B.S. – 1965 University of Washington
Ph.D. – 1970 University of California Berkeley
Postdoc. – 1970-72 University of Illinois
M.F.A. – 2016 Pacific Northwest College of Art/Oregon College of Art and Craft

Over a period of four decades my work was devoted to the investigation of nucleic acids and their nucleobase constituents.  My laboratory designed and synthesized modified nucleosides as potential antiviral and anticancer agents and constructed modified nucleic acids for use as biochemical tools, diagnostic probes, and therapeutics.  The work evolved towards nanotechnology and ultimately integrated concepts of biochemistry, cell biology, self-assembly and nanotechnology, using materials composed of DNA, RNA, peptide nucleic acids, nanoparticles and carbon nanotubes.  Many of these studies involved light mediated processes. 

After 2011 my work shifted to the development of new visual and tactile models of natural phenomena and related philosophical concepts with a particular emphasis on the primordial universe. 

Lab Members
Representative Publications

B. Dorvel, B. Reddy, Jr., I. Block, P. Mathias, S. E. Clare, B. Cunningham, D. E. Bergstrom, R. Bashir, Vapor-Phase Deposition of Monofunctional Alkoxysilanes for Sub-Nanometer-Level Biointerfacing on Silicon Oxide Surfaces, Advanced Functional Materials, 2010, 20, 87-95.

T. Bhuvana1, W. Boley, B. Radha, B.D. Dolash, G. Chiu, D. E. Bergstrom, R. Reifenberger, T.S. Fisher, G.U. Kulkarni, Inkjet printing of palladium alkanethiolates for facile fabrication of metal interconnects and surface-enhanced Raman scattering substrates, Micro & Nano Letters, 2010, 5, 296 – 299.

B. M. Laing, L. Barrow-Laing, M. Harrington, E. C. Long, and D. E. Bergstrom, Properties of Double-Stranded Oligonucleotides Modified with Lipophilic Substituents. Bioconjugate Chem. 2010, 21, 1537– 1544.

P-S. Ng, B. M. Laing, G. Balasundarum, M. Pingle, A. Friedman, and D. E. Bergstrom, Synthesis and Evaluation of New Spacers for Use as dsDNA End-Caps, Bioconjugate Chem. 2010, 21, 1545– 1553.

B. M. Laing, P. Guo, and D. E. Bergstrom, Optimized Method for the Synthesis and Purification of Adenosine -Folic Acid Conjugates for use as Transcription Initiators in the Preparation of Modified RNA, Methods, 2010, doi:10.1016/j.ymeth.2010.12.007.

B. D. Dolash and D. E. Bergstrom, Progress and Road Blocks in the Development of Carbon Nanotubes as Cellular Carriers for Nucleic Acids. In Biomedical Nanotechnology: Handbook of Materials for Nanomedicine; M. M. Amiji, V. P. and Torchilin, Eds., Pan Stanford Publishing, Hackensack, NJ, pp. 723-748, 2011.

B. Reddy, Jr., O. H. Elibol, O Pradeep R. Nair,, B. R. Dorvel, F. Butler, Z. Ahsan, D. E. Bergstrom, M. A. Alam, and R. Bashir, Silicon Field Effect Transistors as Dual-Use Sensor-Heater Hybrids, Anal. Chem., 2011,

L. Tong, Y.  Liu, B. D., Dolash, Y. Jung, M. N. Slipchenko, D. E. Bergstrom, J-X. Cheng,  Label-free imaging of semiconducting and metallic carbon nanotubes in cells and mice using transient absorption microscopy, Nature Nanotechnology,  DOI: 10.1038/NNANO.2011.210, Vol. 7 (1). 

B. M. Laing, D. E. Bergstrom, Evaluation of End-Capped DNA Modules for pRNA Capture and Functionalization, Bioconjugate Chemistry  2012, 23, 683-687.

Y. Guan, C. Bissantz, D. E. Bergstrom, A. Link, 1,2,4-Trisubstituted Cyclopentanes as Platforms for Diversity, Archiv Der Pharmazie, 2012, 345, 677-686.

B. D. Dolash, R. R. Lahuji, D. Y. Zemlyanov, V. P. Drachev, R. Reifenberger, D. E. Bergstrom, Sonication Mediated Covalent Cross-linking of DNA to Single-walled Carbon Nanotubes, Chemical Physics, 2013, 413, 11-19.

V. Zohrabi-Kalantari, A.  Jarrahian, C.  Bissantz, D. E. Bergstrom, E. L. Barker, A. Link,  4-Aminocyclopentane-1,3-diols as Platforms for Diversity: Synthesis of Anandamide Analogs, Medicinal Chemistry, 2013, 9, 881-888.

B. D. Dolash,  R. R. Lahuji, D. Y. Zemlyanov, V. P. Drachev, R. Reifenberger, D. E.  Bergstrom, Sonication Mediated Covalent Cross-linking of DNA to Single-walled Carbon Nanotubes, Chem. Physics, 2013, 413, 11-19.

J. Wanner, D. Romashko, D. S. Werner, E. W. May, Y. Peng, R. Schulz, K.W. Foreman, S. Russo, L. D. Arnold, M. Pingle, D. E. Bergstrom, F. Barany, S. Thomson, Reversible Linkage of Two Distinct Small Molecule Inhibitors of Myc Generates a Dimeric Inhibitor with Improved Potency That Is Active in Myc Over-Expressing Cancer Cell Lines, PLOS ONE, 2015, 10,  Article Number: e0121793, DOI: 10.1371/journal.pone.0121793

S. F. Giardina, D. S. Werner, M. Pingle, K. W.  Foreman, D. E. Bergstrom, L. D. Arnold, F. Barany, Target-Directed Self-Assembly of Homodimeric Drugs Against beta-Tryptase,  ACS Medicinal Chemistry Letters, 2018, 9, 827-831, DOI: 10.1021/acsmedchemlett.8b00204.