New Tools and Therapeutics for the Treatment of Tuberculosis

Speaker: 
Dr. Jeff Aube
Location: 
RHPH 164
Date / Time: 
Thursday, November 10, 2022 - 4:00pm
Host: 
Dan Flaherty
Abstract: 

 

Tuberculosis (TB) is a devastating mycobacterial infection that has been known since antiquity and continues to kill over a million people worldwide annually. Although drugs are available to treat TB, the challenges of lengthy therapies and emerging resistant strains require new treatments, such as drugs that act on novel mechanisms, and tools that enable the greater understanding of Mycobacterial tuberculosis (Mtb), the causative agent of the disease. This presentation will focus on recent collaborative efforts to fulfill these needs, including (1) the discovery of several classes of beta-lactams having anti-TB activity, (2) the search for inhibitors of phosphopantetheinyl phosphate, a newly-validated target against Mtb, and (3) studies of 5-amino-6-D-ribitylaminouracil, an activator of musosal-associated invariant T cells.

 

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