New imaging tools to decipher neural network dysfunction underlying cognitive deficits in epilepsy

Dr. Peyman Golshani - Professor, Departments of Neurology & Psychiatry, David Geffen School of Medicine, UCLA
Date / Time: 
Thursday, September 17, 2020 - 4:00pm
Dr. Yang Yang

Temporal lobe epilepsy is associated with memory deficits but the circuit mechanisms underlying these cognitive disabilities are not understood. We used electrophysiological recordings, open-source wire-free miniaturized microscopy and computational modeling to probe these deficits in a model of temporal lobe epilepsy. We find desynchronization of dentate gyrus interneurons with CA1 interneurons during theta oscillations and a loss of precision and stability of place fields. We also find that emergence of place cell dysfunction is delayed, providing a potential temporal window for treatments. Computation modeling shows that desynchronization rather than interneuron cell loss can drive place cell dysfunction. Future studies will uncover cell types driving these changes and transcriptional changes that may be driving dysfunction.

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