How Do Obesity and Cancer-Associated Mutations Impact Endometrial Cancer Risk?
Excess body weight is a contributing factor in up to 20% of all cancer deaths in women. In particular, endometrial cancer incidence has risen steadily over the past two decades concomitant with the rise in global obesity rates. A major gap in knowledge is how genetic mutations alter endometrial cancer risk in obese women. In this seminar, I will present evidence suggesting that mutations in the phosphoinositide 3-kinase (PI3K) pathway alter the endometrial response to obese phenotypes, resulting in inflammation. As obesity rates continue to rise, there is an urgent need to better understand endometrial cancer pathogenesis and develop preventative measures.