The Eya phosphatase and its unique role in cancer
The Eya proteins were originally identified as essential transcriptional co-activators of the Six family of homeoproteins. Subsequently, the highly conserved C-terminal domains of the Eya proteins were discovered to act as a Tyr phosphatase, making Eyas the first transcriptional activators to harbor intrinsic phosphatase activity. The Eya Tyr phosphatase mediates breast cancer cell transformation, migration, invasion, as well as metastasis, through targets not yet identified. Intriguingly, the N-terminal domain of Eya contains a separate Ser/Thr phosphatase activity implicated in innate immunity and in regulating c-Myc stability. In this talk, I will present our efforts on targeting the Eya’s Tyr phosphatase activity for cancer therapy as well as understanding the molecular mechanism of Eya’s Thr phosphatase activity.