Epigenetic factor CDYL as drug target for neurological and psychological diseases
Plasticity is a fundamental feature of neuronal network, which is constantly shaped by sensory experience and/or spontaneous internal stimuli to adopt to the environment. There are two broadly recognized categories of activity-dependent plasticity: synaptic (Hebbian plasticity) and nonsynaptic (intrinsic plasticity). Intrinsic plasticity is an important component of learning and memory, and impairment of intrinsic plasticity is involved in a range of neurological and psychiatric disorders such as addiction, pain, depression and epilepsy. The induction and maintenance of intrinsic plasticity require alteration of gene transcription, and epigenetic regulation is an important mechanism to alter cell-wide gene expression in response to various environmental stimuli. In this talk, I will discuss our recent work on epigenetic regulation of Chromodomain Y-like (CDYL) protein on sodium channels related to epilepsy (Liu et al, Nat Commun 2017), and other unpublished studies including the potential role of CDYL in depression and preliminary attempt to target this protein for drug screening.