Drugging the undruggable: From TranscriptOMICS to drug-targets to modulating signaling pathways

Dr. Carlos Camacho, Associate Professor of Computational & Systems Biology, University of Pittsburgh School of Medicine
RHPH 164
Date / Time: 
Thursday, February 27, 2020 - 4:00pm
Dr. Chang-Deng Hu

Many high-value pharmaceutical targets are very difficult to drug using traditional approaches, with flexibility or outright intrinsic disorder being the main obstacle. I will describe the origin of disorder in protein interactions and biophysical and omics "out-of-the-box" approaches to drug this new class of targets. Specifically, using gene expression profiles, we validated a machine learning/structural methods approach that reveals important, human-interpretable insights into perturbation-response properties of cellular networks. This methodology allows us to prospectively identified modulators to challenging targets, providing a unique view on the translational potential of gene expression data to various realms of biology and medicine.


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