G. Marc Loudon

Professor Emeritus of Medicinal Chemistry

Education

B.S. in Chemistry (Magna cum laude) - 1964 Louisiana State University
Ph.D. in Physical-Organic Chemistry - 1968 University of California, Berkeley (with D. S. Noyce)
Postdoc. in Biochemistry - 1968-70 University of California, Berkeley (with D. E. Koshland, Jr.)

Research

My laboratory research interests are in mechanism-based drug design, organic reaction mechanisms in aqueous solution, enzyme mechanisms, and peptide chemistry. My last projects included the design, synthesis and evaluation of a family of aziridine-based inhibitors of the HIV protease, carboxy-terminal peptide degradation, and site-specific peptide cleavage reactions. Because of my activities in administration and teaching, I do not have a regular research group. However, I am available to serve on committees and to co-direct projects in other laboratories that are within my areas of expertise.

I am also studying (in collaboration with George Bodner in the Department of Chemistry) teaching and learning in organic chemistry. A current project involves comparison teaching of sophomore organic chemistry using cooperative learning and standard lecture approaches.

Interests

My current active interests are in university administration, teaching, and the developing of instructional materials. I am the author of Organic Chemistry, 5th Edition, published by Roberts and Company, and am a co-author of both Study Guide and Instructor Supplement to accompany that text. I have, in collaboration with George Bodner in the Division of Chemical Education, been developing a group-study approach to teaching organic chemistry, which has been implemented in the last several years in my organic chemistry course at Purdue (which has between 200-300 students). I am currently interested in working on a revision of the chemistry curriculum for pre-pharmacy, pre-medical, pre-biology, and pre-veterinary students.

Service and Engagement

Associate Dean for Research and Graduate Programs for the College of Pharmacy, Nursing, and Health Sciences, 1988-2007.

Teaching

My principal teaching responsibilities are MCMP 204-205 (Organic Chemistry)

Representative Publications

Marc Loudon, Organic Chemistry, 5th Edition. Greenwood Village CO: Roberts and Company, 2008
 
Marc Loudon and Joseph G. Stowell, Study Guide and Solutions Manual to Accompany Organic Chemistry, 5th Edition. Greenwood Village CO: Roberts and Company, 2009
 
G. M. Loudon, Organic Chemistry, 4th Edition. New York: Oxford University Press (2002).
 
G. M. Loudon and Joseph G. Stowell, Study Guide and Solutions Manual to Accompany Organic Chemistry, 4th Edition. New York: Oxford University Press (2002).
 
G. M. Loudon and David M. Allen, Dynamic Organic Chemistry. (Animations to accompany Organic Chemistry, 4th Edition.) New York: Oxford University Press (2003).
 
V. L. Boyd, M. Bozzini, P. J. Guga, R. J. DeFranco, P.-M. Yuan, G. M. Loudon, and D. Nguyen, "Activation of the Carboxy Terminus of a Peptide for Carboxy-Terminal Sequencing," J. Org. Chem., 1995, 60, 2581-2587.
 
R. L. Geahlen, G. M. Loudon, L. A. Paige, and D. Lloyd, "A General Method for Preparation of Peptides Biotinylated at the Carboxy Terminus," Analytical Biochem. 1992, 202, 68-70.
 
G. M. Loudon, "Mechanistic Interpretation of pH-Rate Profiles," J. Chem. Educ. 1991, 68, 973-974.

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