Members

Working Group Description

Members of the Molecular Pharmacology working group are interested in problems relating to drug action at the molecular and cellular levels. Mechanisms of drug action are explored using recombinant proteins, cellular and animal models of disease, biological samples from patients, and computer-based models. Most faculty in this group are members of the Bindley Biosciences Center of Discovery Park, which facilitates and supports interdisciplinary research projects. Members of the Molecular Pharmacology Research working group conduct research in the following areas:

1. Structure-function relationships of transporters targeted by anti-depressants and drugs of abuse
2. Pharmacology of compounds that modulate G-protein-coupled receptors involved in schizophrenia, depression, Tourette's syndrome, Parkinson's disease, and addiction
3. Mechanism of action of drugs that modulate voltage-gated calcium channels involved in cardiovascular disease and type II diabetes
4. Pharmacology of receptor tyrosine kinases and anticancer agents that target these receptors.
5. Discovery of small molecules that block protein aggregation and oxidative stress in aging and neurodegenerative diseases