Members

Working Group Description

Members in the Molecular and Cellular Biology working group share common interests in using various molecular and cellular approaches to investigate the mechanisms of human diseases at the molecular and cellular levels. The research objective of this working group is to identify novel molecular targets for drug development. The members in this working group are also interested in developing novel technologies to facilitate the analysis of molecular and cellular signaling. One of the examples is the development of novel imaging techniques to facilitate the visualization of molecular interactions, drug-macromolecule interactions, and signal transduction events. The research in this working groups relies heavily on the use of common molecular and cellular techniques (molecular cloning, immunoblotting, PCR, luciferase reporter gene assays, cell culture, cell proliferation assays, differentiation and cell death assays, fluorescence microscopy, confocal microscopy, etc.) and some advanced techniques (FRET, BRET, BiFC, biosensors, siRNA knockdown screening, pathway mapping, etc). Members in this working group are specialized in the following research areas:

1. Identification of molecular targets for drug development
2. Signal transduction and visualization of signaling events
3. Visualization of molecular interactions in living cells and living animals
4. Intracellular trafficking of signaling molecules
5. Transcriptional regulation