Department of Medicinal Chemistry and Molecular Pharmacology Personnel - John M. Pezzuto
EducationA.B. in Chemistry, Rutgers University, 1973Ph.D. in Biochemistry, University of Medicine and Dentistry of New Jersey, 1977 National Cancer Institute Postdoctoral Fellow, Department of Chemistry, Massachusetts Institute of Technology, 1977-1979 Instructor of Chemistry, University of Virginia, 1979 Assistant Professor, University of Illinois at Chicago (UIC), 1980-1985 Associate Professor, University of Illinois at Chicago, 1985-1991 Full Professor, College of Pharmacy, UIC, 1991-2002 Full Professor, College of Medicine, UIC, 1994-2002 Distinguished University Professor at the University of Illinois at Chicago, 2002 Head, Department of Medicinal Chemistry and Pharmacognosy, UIC, 1993-1995 Director, Program for Collaborative Research in the Pharmaceutical Sciences, UIC, 1995-1998 Associate Dean for Research and Graduate Education, College of Pharmacy, UIC, 1998-2002 Deputy Director of the UIC Cancer Center, 2000-2002 Interim Head, Department of Medicinal Chemistry and Pharmacognosy, UIC, 2000-2001 Head, Department of Medicinal Chemistry and Pharmacognosy, UIC, 2001-2002 Dean, College of Pharmacy, Nursing and Health Sciences, Purdue University, 2002-2006 Professor of Medicinal Chemistry, Purdue, 2002-2006 Founding Dean, College of Pharmacy, University of Hawaii ResearchCurrent research interests include: natural products as inhibitors of chemical carcinogenesis; biological evaluation of potential cancer chemotherapeutic agents; biospecific isolation of chemotherapeutic agents from plant materials; evaluation of test agents for cancer preventative and therapeutic activity employing animal models. Dr. Pezzuto has been supported by the National Institutes of Health continuously since 1977, and currently serves as the Principal Investigator of a Program Project grant in cancer chemoprevention, and co-investigator for an International Cooperative Biodiversity Group award. Representative PublicationsCuendet, M., Christov, K., Lantvit, D.D., Deng, Y., Hedayat, S., Helson, L., McChesney, J.D., and Pezzuto, J.M. Multiple myeloma regression mediated by bruceantin. Clin. Cancer Res., 10: 1170-1179, 2004. Tan, Y., Yu, R., and Pezzuto, J.M. Betulinic acid-induced programmed cell death in human melanoma cells involves mitogen-activated protein kinase activation. Clin. Cancer Res., 9: 2866-2875, 2003. Kinghorn, A.D., Su, B.-N., Lee, D., Gu, J.-Q., and Pezzuto, J.M. Cancer chemopreventive agents discovered by activity-guided fractionation: An update. Curr. Org. Chem., 7: 213-226, 2003. Mata-Greenwood, E., Cuendet, M., Sher, D., Gustin, D., Stock, W., and Pezzuto, J.M. Brusatol-mediated induction of leukemic cell differentiation and G1 arrest is associated with down-regulation of c-myc. Leukemia, 16: 2275-2284, 2002. Mehta, R.G., Bhat, K.P., Hawthorne, M.E., Kopelovich, L., Mehta, R.R., Christov, K., Kelloff, G.J., Steele, V.E., and Pezzuto, J.M. Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. J. Natl. Cancer Inst., 93: 1103-1106, 2001. Song, L.L., Kosmeder II, J.W., Lee, S.K., Gerhäuser, C., Lantvit, D., Moon, R.C., Moriarty, R.M., and Pezzuto, J.M. Cancer chemopreventive activity mediated by 4'-bromoflavone, a potent inducer of phase II detoxification enzymes. Cancer Res., 59: 578-585, 1999. Alberts, D.S., Colvin, O.M., Conney, A.H., Ernster, V.L., Garber, J.E., Greenwald, P., Gudas, L.J., Hong, W.K., Kelloff, G.J., Kramer, R.A., Lerman, C.E., Mangelsdorf, D.J., Matter, A., Minna, J.D., Nelson, W.G., Pezzuto, J.M., Prendergast, F., Rusch, V.W., Sporn, M.B., Wattenberg, L.W., and Weinstein, B. Prevention of cancer in the next millennium. Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res., 59: 4743-4758, 1999. Jang, M., Cai, L., Udeani, G.O., Slowing, K., Thomas, C.F., Beecher, C.W.W., Fong, H.H.S., Farnsworth, N.R., Kinghorn, A.D., Mehta, R.G., Moon, R.C., and Pezzuto, J.M. Cancer chemopreventive activity of resveratrol, a natural product derived from grapes. Science, 275: 218-220, 1997. Pezzuto, J.M. Plant-derived anticancer agents. Biochem. Pharmacol., 53: 121-133, 1997. Pisha, E., Chai, H., Lee, I.-S., Chagweder, T.E., Farnsworth, N.R., Cordell, G.A., Beecher, C.W.W., Fong, H.H.S., Kinghorn, A.D., Brown, D.M., Wani, M.C., Wall, M.E., Hieken, T.J., Das Gupta, T.K., and Pezzuto, J.M. Discovery of betulinic acid as a selective inhibitor of human melanoma that functions by induction of apoptosis. Nature Med., 1: 1046-1051, 1995. All publications for John M. Pezzuto (an Adobe Acrobat file)This record was last updated on Feb 16, 2009 at 4:27 PM |
