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Department of Medicinal Chemistry and Molecular Pharmacology Personnel - Casey J. Krusemark

Casey J. Krusemark, Ph. D., Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Assistant Professor of Medicinal Chemistry and Molecular Pharmacology
Phone: 494-4679
E-mail: ckrusema@purdue.edu

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Picture of Casey J. Krusemark
Specialization: Chemical biology, DNA-programmed combinatorial chemistry

Education

Postdoctoral Fellow, 2007-2013, Stanford University (Pehr Harbury/Patrick O. Brown)
Ph.D. Biochemistry, 2007, University of Wisconsin--Madison (Peter Belshaw)
B.S. Chemistry, B.S. Crop Science, 2001, University of Illinois--Urbana-Champaign

Research: Chemical biology, DNA-programmed combinatorial chemistry

Research in the Krusemark laboratory focuses on the discovery of functional small molecules using the power of in vitro evolution.  DNA-programmed combinatorial chemistry (DPCC) enables the "translation" of DNA constructs into DNA conjugates with wholly synthetic small molecules, thus allowing Darwinian-like selections.  DPCC allows the synthesis and functional interrogation of small molecule libraries of unprecedented size and complexity (presently up to 10^10 members).

The lab works of the further development of the DPCC technology towards the goal of a streamlined system for generating drug leads and biological tool compounds.  We use a combination of chemical, engineering, and molecular biology methods.  We are working to expand the synthetic toolbox available for builiding molecules on unprotected DNA to produce molecules with more drug-like properties.  Our lab will develop tools to study the protein kinase C (PKC) family of kinases, which are involved in the signal transduction pathways of numerous and varied cellular processes. 

Lab Members:

Kyle Edward Denton (Graduate Student)
Rachael R. Jetson (Post-Doctoral Research Associate)

Teaching

MCMP 204 Organic Chemistry I

Representative Publications

Krusemark, C. J., Tilmans, N. P., Brown, P. O., Harbury, P. B., "Quantitative Population Behavior in Chemical Evolution." In review.

Tilmans, N. P., Krusemark, C. J., Harbury, P. B., “Expedient Synthesis of a Modular Phosphate Affinity Reagent.” Bioconj. Chem.  2010, 21, 1010-1013.

Frey, B. L., Ladror, D. T., Sondalle, S. B., Krusemark, C. J., Jue, A. L., Coon, J. J., Smith, L. M., “Chemical derivatization of peptide carboxyl groups for highly efficient electron transfer dissociation." J. Am. Soc. Mass Spectrom.  2013, 24, 1710-1721.

Krusemark, C. J., Frey, B. L., Belshaw, P. B., Smith, L. M., "Modifying the Charge State Distribution of Proteins in Electrospray Ionization Mass Spectrometry by Chemical Derivatization." J. Am. Soc. Mass Spectrom.  2009, 20, 1617-1625.

Krusemark, C. J., Ferguson, J. T., Wenger, C. D., Kelleher, N. L., Belshaw, P. J., "Global Amine and Acid Functional Group Modification of Proteins."  Analytical Chemistry.  2008, 80, 713-720.

Krusemark, C. J. and Belshaw, P. J., "Covalent Labelling of Fusion Proteins in Live Cells via an Engineered Receptor-Ligand Pair."  Organic and Biomolecular Chemistry. 2007, 5, 2201-2204.

Krusemark, C. J.*,  Lamos, S. M.*, McGee, C. J., Scalf, M., Smith, L. M., Belshaw, P. J.,  "Mixed Isotope Photoaffinity Reagents for Identification of Small Molecule Targets by Mass Spectrometry."  Angewandte Chemie Int. Ed. 2006, 45, 4329-4333.  *Authors contributed equally.

Curriculum Vitae

Click here for a full CV for Casey J. Krusemark. (an Adobe Acrobat file)

This record was last updated on Dec 21, 2013 at 1:28 PM
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